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What’s Actually Inside Pineal Guardian X?
Pineal Guardian X contains 11 ingredients: Lion’s Mane Mushroom, Bacopa Monnieri, Ginkgo Biloba, French Maritime Pine Bark Extract, Spirulina, Chlorella, Moringa Extract, Heritage Tamarind Extract, Neem, Boron, and Lemon Juice Powder.
The formula is delivered as a liquid dropper at 2ml per day (two full squeezes). Nutraville, the manufacturer, states that each ingredient is individually disclosed on the label with no proprietary blends — a transparency point that matters when evaluating any supplement.
The core marketing story positions the formula around “pineal gland decalcification” — the idea that fluoride and calcium deposits accumulate in the pineal gland and that these ingredients can flush them out. As we’ll show below, some of that science is real, some of it is stretched, and the most valuable ingredients work on entirely different mechanisms that have nothing to do with fluoride.
Bottom line upfront: Four of the eleven ingredients have strong clinical research behind them. Three have solid supporting roles. The remaining four add antioxidant and detox value but with thinner direct evidence. The formula as a whole is well-constructed for a brain and cognitive support supplement — better than most in this space.
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1. Lion’s Mane Mushroom (Yamabushitake) — Hericium erinaceus
Role in the formula: Primary nootropic — neuroplasticity and memory support
Lion’s Mane is the most research-backed ingredient in Pineal Guardian X. Known as “Yamabushitake” in Japanese traditional medicine, it has been used in Chinese and Japanese medicine for centuries — originally for what the Song Dynasty pharmacopoeia called “lion-roar disease,” which researchers now believe may have described dementia-like symptoms.
The key compounds are hericenones (found in the fruiting body) and erinacines (found in the mycelium). Both converge on the same critical pathway: stimulating Nerve Growth Factor (NGF).
NGF is a protein your brain needs for:
- Neuron growth, maintenance, and survival
- Synaptic plasticity (how well your brain forms and retains memories)
- Protection against neurodegeneration
- Cholinergic neuron maintenance (the neurons most associated with memory)
NGF levels decline naturally with age, and that decline is directly linked to cognitive decline and increased Alzheimer’s risk. Erinacine A, specifically, is one of the few naturally occurring compounds that can cross the blood-brain barrier to stimulate NGF production directly inside the brain.
A 2024 study in the Journal of Neurochemistry showed Lion’s Mane extract significantly increased NGF levels and improved synaptic plasticity in animal models. A 2025 meta-analysis of 12 human trials found daily Lion’s Mane users showed measurable improvements in working memory and attention compared to placebo groups.
Important caveat: Quality varies massively between products. The Lion’s Mane “fruiting body” extract (which contains hericenones) and “mycelium” extract (which contains erinacines) work through different mechanisms. Pineal Guardian X doesn’t specify which extraction method it uses — and the effectiveness depends heavily on this. High-quality dual extracts cost more to produce than standard powders.
Evidence rating: Strong (A-tier)
2. Bacopa Monnieri — Bacopa monnieri
Role in the formula: Primary memory enhancer — information retention and recall speed
Bacopa is one of the most clinically validated natural memory nootropics available. It has been used in Ayurvedic medicine for over 3,000 years under the name “Brahmi” — literally meaning “that which gives supreme knowledge.”
The active compounds are called bacosides, particularly bacosides A and B. They work by:
- Supporting the repair and growth of nerve dendrites (the branching structures that transmit information between neurons)
- Enhancing acetylcholine neurotransmitter activity — the primary chemical involved in memory formation
- Inhibiting acetylcholinesterase, the enzyme that breaks down acetylcholine (same target as some Alzheimer’s drugs)
- Reducing cortisol levels, which improves learning under stress
The research on Bacopa is extensive. A 2023 meta-analysis confirmed that standardized Bacopa extracts significantly improve information processing speed, working memory, and attention span in healthy adults. The evidence is consistent across multiple independent research groups over three decades.
The critical timing issue: Bacopa does not work acutely. A double-blind, placebo-controlled 12-week trial at 300mg daily (standardized to 55% bacosides) showed memory improvements that appeared at the 5-week mark and grew stronger through week 12. Single doses produce no measurable cognitive improvement. This is the most important thing to understand about Bacopa — and by extension, Pineal Guardian X.
Standard clinical dose: 300–600mg/day of standardized extract. Pineal Guardian X doesn’t disclose individual ingredient amounts, which makes it hard to verify whether it hits this range.
Evidence rating: Strong (A-tier)
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3. Ginkgo Biloba
Role in the formula: Cerebral circulation — oxygen and nutrient delivery to the brain
Ginkgo Biloba is one of the oldest and most studied botanicals for cognitive health. The active compounds — ginkgolides and bilobalide — work primarily through two mechanisms:
- Vasodilation: Ginkgo improves blood flow through the brain’s microvasculature, increasing oxygen and glucose delivery to neurons. This is probably the fastest-acting effect in the entire formula
- Platelet aggregation inhibition: Ginkgo mildly thins the blood and reduces microclotting in cerebral vessels — a benefit for cognitive circulation, but also the reason it interacts with blood-thinning medications
Dozens of clinical trials support Ginkgo’s role in supporting memory, attention, and mental clarity, particularly in aging adults. Unlike Bacopa, Ginkgo can produce measurable circulation effects relatively quickly — some studies note improvements within 1–4 weeks.
Standard dose: 120–240mg/day of standardized extract (24% ginkgoflavonglycosides, 6% terpene lactones).
Drug interaction alert: Ginkgo has well-established mild anticoagulant effects. If you take warfarin, aspirin regularly, NSAIDs, or other blood thinners, talk to your doctor before taking Pineal Guardian X.
Evidence rating: Strong (A-tier)
4. French Maritime Pine Bark Extract — Pinus pinaster
Role in the formula: Antioxidant neuroprotection — protecting neurons from oxidative damage
French Maritime Pine Bark Extract (standardized as Pycnogenol in many studies) contains a class of compounds called proanthocyanidins — some of the most potent antioxidants found in nature.
In the brain specifically, Pine Bark Extract:
- Scavenges free radicals that damage neurons over time
- Reduces oxidative stress in cerebral tissue
- Supports nitric oxide production, improving blood flow alongside Ginkgo’s effects
- Has anti-inflammatory effects that protect against neuroinflammation — a driver of cognitive decline
Research links Pine Bark Extract to improvements in attention, focus, and memory in both young adults and aging populations. A study in healthy professionals found 8 weeks of supplementation improved attention, mental energy, and reduced fatigue.
Pine Bark pairs well with Ginkgo in this formula — both support cerebral circulation through complementary mechanisms. Together they create a broader vascular protection effect than either alone.
Evidence rating: Strong (B+ tier)
5. Premium Spirulina — Arthrospira platensis
Role in the formula: Systemic antioxidant — anti-inflammatory baseline support
Spirulina is a blue-green algae that’s one of the most nutrient-dense foods on earth. It contains phycocyanin — a compound that gives spirulina its distinctive color and has potent antioxidant and anti-inflammatory properties.
In the context of a brain supplement:
- Spirulina’s antioxidants reduce systemic oxidative stress that contributes to brain aging
- Phycocyanin specifically inhibits inflammatory enzymes that, when chronically elevated, damage neural tissue
- Spirulina provides natural iodine, vitamin B12 (in a limited form), iron, and essential amino acids that support neurological function
- Some research suggests spirulina may support neuroprotection and reduce neurotoxicity from environmental exposures
It’s a quality supportive ingredient — not a primary cognitive enhancer in itself, but a meaningful addition to reduce the inflammatory background that accelerates cognitive decline.
Side effect note: Spirulina contains natural iodine. If you have thyroid conditions or take thyroid medication, check with your doctor. Some people with iodine sensitivity also report mild digestive upset.
Evidence rating: Solid (B-tier for cognitive support role)
6. Pure Chlorella — Chlorella vulgaris
Role in the formula: Heavy metal chelation and detox support
Chlorella is a single-celled freshwater algae. Its primary relevance in Pineal Guardian X is its chelating properties — the ability to bind to heavy metals and assist in their elimination from the body.
Chlorella’s cell wall contains a fibrous material that has been studied for binding to mercury, lead, cadmium, and other heavy metals in the digestive tract, reducing absorption and supporting excretion.
The “pineal detox” marketing ties chlorella to removing fluoride and calcium deposits from the pineal gland. The honest assessment: chlorella does have documented heavy metal chelating activity in the gut, and some researchers have explored its role in reducing overall toxic metal burden. Whether this translates specifically to pineal calcification reversal is a step further than the published science confirms.
What is well-supported: reducing overall toxic metal accumulation in the body is genuinely beneficial for brain health and reduces the inflammatory burden on neural tissue. On that basis, chlorella earns its place in this formula.
Chlorella also provides chlorophyll, vitamins B12, K, and iron, adding nutritional baseline support.
Evidence rating: Solid (B-tier for detox role)
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7. Moringa Extract — Moringa oleifera
Role in the formula: Multi-nutrient brain support — reducing neuroinflammation and supporting energy
Moringa is often called the “miracle tree” and is one of the most nutrient-dense plants studied. It contains over 90 different nutrients, including vitamins A, B, C, E, calcium, potassium, and a broad array of amino acids and antioxidants.
For brain health specifically:
- Moringa contains isothiocyanates — compounds with documented anti-inflammatory effects that cross the blood-brain barrier and reduce neuroinflammation
- It helps regulate blood sugar levels, which matters for brain energy — the brain is a glucose-dependent organ and blood sugar instability directly impairs cognitive performance
- Animal studies show Moringa extract reduces markers of oxidative stress in brain tissue and may help protect against neurotoxicity
- Its high B-vitamin content supports neurological function and energy metabolism in neurons
Moringa isn’t a primary cognitive enhancer, but it’s a genuinely valuable supportive ingredient — particularly for people whose brain fog is partly related to metabolic or inflammatory issues rather than pure neurotransmitter deficits.
Evidence rating: Solid (B-tier)
8. Heritage Tamarind Extract — Tamarindus indica
Role in the formula: Fluoride chelation support — the “pineal detox” connector
Tamarind is the ingredient most central to Pineal Guardian X’s marketing story. Here’s what the research actually shows:
A study published in PubMed (referenced by multiple sources as the “tamarind defluoridation” study) found that tamarind consumption increased urinary fluoride excretion in children living in a high-fluoride area. The researchers concluded that tamarind may help the body excrete fluoride more efficiently.
Tamarind contains tartaric acid, malic acid, and galactomannans — compounds with known chelating properties that can bind to fluoride ions and assist in their removal through the kidneys.
The honest assessment: the evidence that tamarind helps the body excrete fluoride from urine is real, though limited in scope. The leap from “helps excrete fluoride” to “decalcifies the pineal gland” is larger than the research directly supports. The pineal gland calcification process involves calcium phosphate and calcium fluoride deposits that have built up over years — flushing out new fluoride intake is different from dissolving existing deposits.
Tamarind also has antioxidant, anti-inflammatory, and antimicrobial properties that add general value to the formula regardless of the fluoride angle.
Evidence rating: Promising (C+ tier for the pineal-specific claim; B-tier for general antioxidant/chelation value)
9. Elder Mahogany Neem — Azadirachta indica
Role in the formula: Anti-inflammatory, antimicrobial, and detox support
Neem is one of the most widely used plants in Ayurvedic medicine, valued for its broad-spectrum antibacterial, antifungal, anti-inflammatory, and antioxidant properties.
In this formula, Neem contributes to:
- Reducing systemic inflammation that can affect brain health
- Supporting liver detoxification pathways that reduce the overall toxic burden on the body
- Antioxidant protection against free radical damage
Neem is also likely responsible for much of the “earthy/herbal/licorice-like” taste that users frequently complain about. This is worth knowing before you buy — mixing the drops in orange juice significantly reduces the intensity of the flavor compared to water.
Direct cognitive research on Neem is limited. Its value in this formula is primarily as a systemic anti-inflammatory and detox supporter rather than a nootropic in its own right.
Evidence rating: Supportive (C+ tier)
10. Boron
Role in the formula: Calcium metabolism regulation — the pineal calcification limiter
Boron is a trace mineral with several well-documented roles in human physiology. In the context of Pineal Guardian X, its inclusion is specifically tied to the decalcification concept:
- Boron modulates parathyroid hormone (PTH) levels — and PTH directly controls how much calcium is deposited in soft tissues
- By reducing PTH activity, boron may help limit the ongoing deposition of calcium in areas like the pineal gland
- Boron also supports magnesium retention and vitamin D metabolism, both of which affect calcium regulation
There’s also separate research showing boron supports cognitive function more directly. A small clinical trial found that adults deficient in boron showed impaired attention, perception, and memory — and that restoring boron levels improved those scores.
The typical dietary intake in Western diets is 1–3mg/day. The common supplemental range used in studies is 3–6mg/day. Boron is one of the few ingredients in this formula where the mechanism connecting it to pineal calcification is actually plausible — the PTH-calcium pathway is a real and established mechanism.
Evidence rating: Solid (B-tier — the most scientifically plausible “decalcification” ingredient in the formula)
11. Lemon Juice Powder
Role in the formula: Bioavailability enhancer and alkalizing agent
Lemon Juice Powder is the simplest ingredient in the formula. It provides natural citric acid and vitamin C, which serve two functions:
- Bioavailability enhancement: Citric acid can improve the absorption of minerals and some plant compounds by creating a more acidic environment in the digestive tract that aids solubilization
- Antioxidant support: Vitamin C is a direct antioxidant and also regenerates other antioxidants (like vitamin E) in the body
Some wellness sources suggest citric acid may help break down calcium deposits (given that lemon is acidic), but applying this to internal pineal calcification is a significant scientific stretch. At the amounts present in a supplement serving, the systemic pH effect is negligible.
Its primary value is functional — improving the overall bioavailability of the other ingredients and adding vitamin C support.
Evidence rating: Supportive (C-tier as a standalone; functional value as a bioavailability enhancer)
How the Ingredients Work Together
One thing most ingredient breakdowns miss is how the components interact. In Pineal Guardian X, the 11 ingredients fall into four functional layers:
| Layer | Ingredients | What They Do Together |
|---|---|---|
| Cognitive Enhancement Core | Lion’s Mane, Bacopa Monnieri | NGF stimulation + memory consolidation. These work on slow, structural improvements over weeks. The foundation of the formula’s brain-building effects. |
| Circulation & Delivery | Ginkgo Biloba, Pine Bark Extract | Improve blood flow and oxygen delivery to brain cells, making the nootropic ingredients more effective. Ginkgo vasodilates; Pine Bark inhibits oxidative damage to vessels. |
| Anti-Inflammatory Shield | Spirulina, Moringa, Neem | Reduce the chronic neuroinflammation that silently erodes cognitive function over time. Important background protection, not acute enhancers. |
| Detox & Mineral Support | Chlorella, Tamarind, Boron, Lemon Juice Powder | Support heavy metal chelation, calcium metabolism, and bioavailability. The “pineal detox” group — mixed evidence strength, but Boron is the most scientifically grounded here. |
The formula is thoughtfully layered in the sense that each ingredient doesn’t just target the same pathway. The combination of a cognitive builder (Lion’s Mane + Bacopa) with a circulation booster (Ginkgo + Pine Bark) with an anti-inflammatory shield (Spirulina + Moringa + Neem) creates a more complete cognitive support profile than most single-mechanism nootropics.
Ingredient Tier Rankings: Honest Assessment
This table is something you won’t find on any other review — a tiered ranking of each ingredient based purely on the quality and relevance of the published evidence:
| Ingredient | Evidence Tier | Primary Benefit | Time to Effect |
|---|---|---|---|
| Lion’s Mane | A (Strong) | NGF, neuroplasticity, memory | 4–8 weeks |
| Bacopa Monnieri | A (Strong) | Memory consolidation, recall speed | 8–12 weeks |
| Ginkgo Biloba | A (Strong) | Cerebral blood flow, attention | 1–4 weeks |
| Pine Bark Extract | B+ (Solid) | Antioxidant protection, focus | 4–8 weeks |
| Spirulina | B (Solid) | Antioxidant, anti-inflammatory baseline | Ongoing |
| Moringa | B (Solid) | Neuroinflammation, blood sugar | Ongoing |
| Boron | B (Solid) | Calcium metabolism, PTH regulation | Ongoing |
| Chlorella | B- (Solid for detox) | Heavy metal chelation | Ongoing |
| Tamarind | C+ (Promising) | Fluoride excretion support | Ongoing |
| Neem | C+ (Supportive) | Anti-inflammatory, liver detox | Ongoing |
| Lemon Juice Powder | C (Functional) | Bioavailability enhancement | Immediate |
What this tells you: Three ingredients are genuinely strong (Lion’s Mane, Bacopa, Ginkgo). Four are solid supporters. The rest are meaningful additions but with thinner direct cognitive evidence. The formula as a whole is stronger than most in this category, but it’s carried by the top three.
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What the Formula Is Missing
No formula is perfect. Here are ingredients that would strengthen Pineal Guardian X’s cognitive support profile that are notably absent:
- Phosphatidylserine (PS): One of the strongest-evidence cognitive support compounds — directly involved in neuron membrane integrity and memory. Multiple RCTs support its benefit, and it’s FDA-approved for qualified cognitive health claims. Its absence is the biggest gap in this formula
- Omega-3 DHA: The brain’s primary structural fatty acid. Critical for synaptic membrane health, and consistently supported in cognitive research. Not present here
- Vitamin D3: Heavily involved in brain function, neuroprotection, and mood regulation. Deficiency is extremely common and directly impairs cognition. Not included
- Magnesium L-Threonate: The only form of magnesium that crosses the blood-brain barrier — emerging research links it to improved synaptic density and memory. Absent here
This isn’t a fatal criticism — no single supplement contains everything. But if you’re buying Pineal Guardian X as your only cognitive support supplement, knowing what’s missing helps you decide whether to pair it with others.
For a comparison with another brain supplement that uses a different approach to the ingredients above, our PhytoMem One review covers a formula that takes a more targeted memory-specific stack.
Side Effects by Ingredient: What to Watch For
This table maps the most common side effects to the specific ingredients that cause them — something most reviews don’t do:
| Side Effect | Responsible Ingredient(s) | How Common? | How to Minimize |
|---|---|---|---|
| Nausea / digestive upset | Bacopa Monnieri, Spirulina, Chlorella | Most common complaint (10–15% of users) | Take with food, not on empty stomach |
| Mild headache (first few days) | Ginkgo Biloba (circulation effects), Boron | Occasional (first week) | Start with half dose for 3–5 days |
| Earthy/bitter taste | Neem, Tamarind, Chlorella | Very common — not a side effect, just taste | Mix into orange juice instead of water |
| Jitteriness (rare) | Reported by one elderly user at Nutraville (75yo, 150lb, with morning coffee) | Rare — sensitivity-related at full dose | Split dose — half morning, half afternoon |
| Thyroid interactions | Spirulina (iodine content) | Rare but significant for susceptible people | Consult doctor if on thyroid medication |
| Blood thinning interaction | Ginkgo Biloba | Clinically relevant for people on anticoagulants | Check with doctor if on blood thinners |
| Increased stool frequency | Bacopa Monnieri | Occasional — documented in clinical literature | Usually resolves after week 1–2 |
For most healthy adults, the formula is low-risk. The risk profile increases meaningfully for people on blood thinners, thyroid medications, or immunosuppressants. Always check with a healthcare provider if you take any prescription medications.
Frequently Asked Questions About Pineal Guardian X Ingredients
Are all the ingredients natural?
Yes. All 11 ingredients are plant-based, algae-based, or naturally derived. The formula is certified non-GMO, vegan, and gluten-free. No artificial stimulants, synthetic fillers, or animal products.
Does Pineal Guardian X disclose individual ingredient dosages?
Nutraville states that each ingredient is individually disclosed on the label with no proprietary blends. However, the specific milligram amounts per ingredient are not prominently published in marketing materials — they appear on the physical product label. This is important because the effective dose for Bacopa in clinical research is typically 300mg/day, and without knowing the exact amount in a 2ml serving, it’s hard to verify whether the formula hits clinical thresholds.
Which ingredient in Pineal Guardian X works fastest?
Ginkgo Biloba is the fastest-acting ingredient — cerebral circulation effects have been measured within 1–4 weeks in clinical studies. Lion’s Mane’s anti-inflammatory effects can also be felt relatively early. The memory-specific benefits from Bacopa take the longest (8–12 weeks).
Is there any Lion’s Mane in Pineal Guardian X and is it the fruiting body or mycelium?
Yes, Lion’s Mane is listed as an ingredient (as Yamabushitake). Pineal Guardian X doesn’t publicly specify whether it uses fruiting body extract, mycelium extract, or a dual extract. This matters because fruiting body contains hericenones (peripherally active) and mycelium contains erinacines (which cross the blood-brain barrier). Dual extracts are most valuable but also most expensive to produce. If you want to verify, the product label on the bottle should specify.
Can I take Pineal Guardian X with other supplements?
Generally yes, but watch for combinations that stack blood-thinning effects (Ginkgo + fish oil + vitamin E + aspirin = significant anticoagulation risk). Also avoid stacking with other iodine-heavy supplements if you have thyroid concerns. As always, discuss with a healthcare provider if you take any prescription medications.
Does Pineal Guardian X contain caffeine or stimulants?
No. The formula is explicitly stimulant-free. None of the 11 ingredients are stimulants. This is why it doesn’t cause jitteriness in most users and why one unusual report of jitteriness (from a 75-year-old man who combined the supplement with morning coffee) is more likely a caffeine interaction than a formula issue.
Is the “pineal detox” ingredient story real or marketing?
Partially real. Pineal gland calcification is a real, documented phenomenon. Fluoride does accumulate in the pineal gland at unusually high concentrations. Boron’s role in regulating calcium deposition via PTH is physiologically sound. Tamarind has been shown to increase urinary fluoride excretion in controlled studies. Chlorella binds heavy metals in the gut. The overall “fluoride detox” narrative, however, is overstated — none of these ingredients have been proven to dissolve existing pineal calcification in clinical trials. The cognitive benefits you may actually experience will most likely come from Lion’s Mane, Bacopa, and Ginkgo, not from pineal decalcification.
Final Verdict on the Pineal Guardian X Formula
The ingredient profile of Pineal Guardian X is one of the strongest in the pineal/brain supplement category — as long as you judge it on the right criteria.
The top four ingredients (Lion’s Mane, Bacopa Monnieri, Ginkgo Biloba, Pine Bark Extract) represent some of the most clinically validated natural cognitive support compounds available. They work on real, documented mechanisms — NGF stimulation, cerebral circulation, synaptic memory consolidation, and neuroprotection. The supporting cast (Spirulina, Moringa, Boron, Chlorella) adds meaningful antioxidant and metabolic coverage.
The formula’s weakness is the “pineal fluoride detox” marketing that overpromises on what Tamarind, Chlorella, and Neem can realistically accomplish. The science for those claims is thinner than the marketing suggests. But that doesn’t undermine the core formula.
If you’re evaluating this supplement purely on ingredient quality relative to price, the 6-bottle bundle at $39/bottle compares favorably to building the same core stack of Lion’s Mane + Bacopa + Ginkgo + Pine Bark as individual supplements — and you get seven additional supporting ingredients on top.
The 365-day money-back guarantee exists because the most important ingredients (especially Bacopa) genuinely require 8–12 weeks to show their full effects. That’s enough time to give the formula a fair test — and enough safety net to get your money back if it doesn’t work for you.
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Related Reading
- Pineal Guardian X Full Review 2026 — The complete honest verdict on whether the product is worth buying, beyond just the ingredients
- PhytoMem One Review 2026 — A comparison brain supplement with a different ingredient angle; worth reading if you’re deciding between options
- Neuro Serge Review 2026 — Another cognitive supplement with a different formula structure worth comparing
- The Memory Wave Review — A non-supplement approach to memory support; useful context if you’re weighing different formats
- PhytoMem One Ingredients Breakdown — A direct ingredient-level comparison in the same memory supplement space
About the Author: This article was produced by the editorial team at ReviewLab.ng, focused on evidence-based supplement analysis. We earn affiliate commissions if readers purchase through our links. This does not affect our editorial conclusions.
Updated: September 2026
Disclaimer: This article is for informational and educational purposes only and does not constitute medical advice. Pineal Guardian X is a dietary supplement not evaluated by the FDA for treatment or prevention of any disease or condition. Individual results will vary. If you take prescription medications or have any health condition, consult a licensed healthcare provider before starting any new supplement. The 365-day refund policy is subject to Nutraville’s terms and conditions.